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Control of the initiation of
homeotic gene expression by the gap genes giant and
tailless in Drosophila.
Reinitz J, Levine M
Department of Biological Sciences, Fairchild Center,
Columbia University, New York, New York 10027.
The process of segmentation in Drosophila is controlled
by both maternal and zygotic genes. Members of the gap
class of segmentation genes play a key role in this
process by interpreting maternal information and
controlling the expression of pair-rule and homeotic
genes. We have analyzed the pattern of expression of a
variety of homeotic, pair-rule, and gap genes in
tailless and giant gap mutants. tailless acts in two
domains, one anterodorsal and one posterior. In its
anterior domain tailless exerts a repressive effect on
the expression of fushi tarazu, hunchback, and
Deformed. In its posterior domain of action, tailless
is responsible for the establishment of Abdominal-B
expression and demarcating the posterior boundary of
the initial domain of expression of Ultrabithorax.
giant is an early zygotic regulator of the gap gene
hunchback: in giant- embryos, alterations in the
anterior domain of hunchback expression are visible by
the beginning of cycle 14. giant also regulates the
establishment of the expression patterns of
Antennapedia and Abdominal-B. In particular, giant is
the factor that controls the anterior limit of early
Antennapedia expression.
PMID: 1972684, UI: 90292349
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